Synthesis of Some Esters of Acids Containing Nitrogen with Metronidazole

In order to find replacer for Metronidazole and drug selection.Some diesters or esters of acids containing nitrogen with Metronidazole were designed and synthesized,which have difference in water\|solubility.Metronidazole was reacted with the corresponding amino or imino multi\|carboxylic acid compounds in the presence of acetic anhydride or thionyl chloride or DCC.The intermediate of nitrilotriacetic acid with Ac\-2O was identified by Mass Spectrum.Out of three diesters two are novel.