The Synthesis and Anti-MRSA Activity of Amidinium-Substituted 2-Dibenzofuranylcarbapenems.
2000
A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a consequence of the positively charged amidinium substituent.
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