High Serum Tumor Necrosis Factor Receptor 1 Levels Are Related to Risk of Low Intrinsic Capacity in Elderly Adults

To explore the association between inflammatory cytokines and intrinsic capacity in older adults. Data were retrieved from the Cardiovascular Health, Cognition and Aging Study. A total of 130 participants aged 60–99 years (mean age 73.11±9.02 years) were recruited. Intrinsic capacity was assessed by the five domains recommended by the World Health Organization: locomotion, cognition, vitality, sensory and psychological domains. Circulating interleukin-6, tumor necrosis factor receptor 1 (TNFR1), insulin-like growth factor-1, and vaspin levels were measured. Logistic regression was conducted for factors associated with intrinsic capacity decline. Intrinsic capacity decline was associated with older age, kidney diseases, olfactory disturbances and lower grip strength. Logistic regression showed that circulating TNFR1 was independently associated with intrinsic capacity decline after adjustments for age, sex, education, chronic diseases, grip strength, and physical activity. Elevated circulating TNFR1 levels are independently associated with declined intrinsic capacity, suggesting that chronic inflammation may underlie intrinsic capacity decline.