CircPVT1: a bridge linking Hippo pathway and human cancers

The Hippo pathway, first discovered in Drosophila (1), plays an important role in regulating the size of tissues and organs, and maintains homeostasis by modulating cell proliferation and apoptosis. The Hippo pathway itself is regulated by intrinsic cell signals, such as cell polarity, cell-cell contact, and by the actin cytoskeleton (2).