N-acetyltransferase 2 genotype-related efficacy of sulfasalazine in patients with rheumatoid arthritis.

Shunichi Kumagai,Fusao Komada,Tomoko Kita,Akio Morinobu,Shoichi Ozaki,Hiroshi Ishida,Hajime Sano,Tsukasa Matsubara,Katsuhiko Okumura

N-acetyltransferase 2 genotype-related efficacy of sulfasalazine in patients with rheumatoid arthritis.

2004

Shunichi Kumagai
Fusao Komada
Tomoko Kita
Akio Morinobu
Shoichi Ozaki
Hiroshi Ishida
Hajime Sano
Tsukasa Matsubara
Katsuhiko Okumura

Purpose. For the individual optimization of drug therapy with sulfasalazine (SASP), we studied the influence of the N-acetyltransferase 2 (NAT2) genotype on the pharmacokinetics, efficacy, and incidence of adverse reactions of SASP in patients.

Keywords:

Sulfasalazine
Rheumatoid arthritis
Genotype
Pharmacology
Chemistry
Pharmacokinetics
Adverse effect
Sulfapyridine
Polymorphism (computer science)
Genotyping
Heterozygote advantage
Genotype frequency

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