High bioavailability proton pump inhibitor sustained-release technique

The invention discloses proton pump inhibitor slow-release technology with high bioavailability. A micropill is prepared from a drug-containing pill core coated slow-release coating. The micropill has the advantages of higher bioavailability, good slow-release property, convenient use, low medicine taking frequency and more stable blood drug concentration, and can avoid the acid breakthrough at night and lower untoward reactions.