Lipoprotein-Associated Phospholipase A2 and Ischemic Cardio - Cerebrovascular Diseases

Lipoprotein-associated phospholipase A2 （Lp-PLA2） is a specific marker reflecting vascular inflammation which is produced predominantly by macrophages. It plays an important role in the oxidation of low density lipoprotein, progression of artherosclerosis and coronary heart disease, as well as the development of stroke. The increased levels of Lp-PLA2 are an independent risk factor for predicting the risks of coronary heart disease and stroke. Key words: lipoprotein-associated phospholipase A2;  cardiovascular diseases;  cerebrovascular disease;  atherosclerosis;  inflammation