Effects of changes in afterload on regional wall motion in acute ischemic canine heart.

SAKUMA, M., SHIRATO, K., OIKAWA, Y., KATOH, A., NAKAGAWA, M., ISHIGAKI, H. and TAKISHIMA, T. Effects of Changes in Afterload on Regional Wall Motion in Acute Ischemic Canine Heart. Tohoku J. Exp. Med., 1993, 169 (1), 31-41- The aim of the present study was to examine effects of changes in afterload on regional myocardial motion in acute ischemia. Ischemic and non-ischemic segment lengths of the left ventricular free wall were measured by miniature ultrasonic gauges in eleven open chest dogs with the pericardium preserved. In a stable state after left anterior descending coronary artery occlusion, peak left ventricular pressure was varied by the infusion of angiotensin II (n=8) and sodium nitroprusside (n=8). To exclude effects of preload on the responses, end-diastolic lengths of the non-ischemic region before and during infusion of each drug were matched with vena caval occlusion. When peak left ventricular pressure elevated from 113±2 (mean±S.E.)mmHg to 145±6, in isovolumetric contraction phase, degree of active shortening in the non-ischemic region and that of paradoxical expansion of the ischemic region did not change. In ejection phase, active shortening of the non-ischemic region decreased from 1.38±0.11mm to 1.06±0.10 but that of the ischemic region remained unchanged. Stroke volume decreased from 14.5± 1.3ml to 10.8±1.0. When peak left ventricular pressure decreased from 111±4 mmHg to 101±6, in isovolumetric contraction phase, active shortening of the non- ischemic region decreased from 0.90±0.13mm to 0.76±0.15 and paradoxical expansion of the ischemic region reduced from -0.95±0.11mm to -0.80±0.11. In ejection phase, shortening of the non-ischemic region increased from 1.05±0.13 mm to 1.31±0.15 but that of the ischemic region did not change. Stroke volume increased from 11.5±1.3ml to 14.0±1.4. These results indicate that in acute ischemia, changes in isovolumetric shortening of the non-ischemic region and paradoxical expansion of ischemic region are related with each other in isovolumetric contraction phase when afterload is altered and suggest that stroke volume is affected by the shortening of ejection phase in the non-ischemic region. -angiotensin II; sodium nitroprusside; pericardium