Prognostic value of patient-reported outcomes (PROs) in advanced cancer.

8Background: Performance status, which is prognostic of survival, is a physician’s interpretation of PROs. This retrospective study evaluated prognosis of PROs, independent of physician assessment, with overall survival (OS) and hospitalization-free survival (HFS). Methods: Patients (pts) at HCI were assessed using the NCI PROMIS-Ca bank from May 2016. Physical function (PF), fatigue, depression, anxiety, and pain scores were collected via iPad in pts with metastatic cancers. A single PRO score collected within 6 months of metastatic diagnosis for each pt was merged with outcome data using the Flatiron Health database. Associations between PROs, gender, cancer type, OS and HFS were assessed. Results: 287 complete sets of pt data were available. The PRO domains were interrelated with moderate-strong correlations (0.40-0.79). Cancer types differed by OS and HFS (p’s < 0.001). PF scores were worse for NSCLC than other cancers (p < 0.001). Individual PRO scores were worse for women than men, HFS was better fo...