Synthesis of tetrahedral diarylheptanoid ent-diospongin A and epimer-diospongin B by employing Julia–Kocienski olefination

Abstract Total synthesis of ent -diospongin A and epimer -diospongin B has been accomplished in good yield with high optical purity. The key steps of diospongin synthesis involve Julia–Kocienski olefination, Weinreb amide formation, Grignard reaction, reduction, acetonide deprotection, Lewis acid catalyzed cyclization, and Wacker oxidation.