Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin - Implications for Dual Inhibitor Design with Angiotensin Converting Enzyme.

Neprilysin (NEP) and angiotensin-1 converting enzyme (ACE) are two key zinc-dependent metallopeptidases in the natriuretic peptide and kinin systems, and renin-angiotensin-aldosterone system, respe...