Role of Circular RNA in Melanoma Development: A Review

Malignant melanoma, a tumor derived from melanocytes shows severe drug resistance and prompts metastasis, causing a serious threat to human health. Emerging evidence indicates that Circular RNAs (circRNAs) are widely expressed in mammals and play crucial roles tumorigenesis by regulating miRNA, downstream gene expression and protein production. The role of circRNA in pathogenesis of melanoma has been recently reported and highlighted. This review may provide a new landscape for the role of circRNA in melanoma.