A case of hepatosplenomegaly presenting as abnormal fibrinolytic states

A case of Hepatosplenomegaly associated with Pancytopenia, bleeding tendency and markedly shortened Euglobulin Clot Lysis Time (ELT) was presented. The patient was undergone Splenectomy aiming of recovery from Pancytopenia. Histologically spleen showed Splenitis-like changes. It is of interest ELT recovered to normal range after Splenectomy. Therefore, the results of fibrinolytic data obtained were as followed.1) In vitro, ELT of normal plasma was shortened in addition of patient's plasma to normal plasma.2) t-AMCHA and Trasylol prolonged ELT of patient's plasma in vitro and in vivo.3) Patient's plasma and euglobulin did not so strongly hydrolyze TAME, AGLME, S-2251, S-2238 and RM601-1 (Pentapharm).4) A supernatant of homogenized spleen digested Bovine Standard Fibrin Plate, but not Bovine Plasminogen free Fibrin Plate and also this supernatant did not inhibit Plasmin and Urokinase.From these results, fibrinolytic system of this case was specific, and it might be suggested that the spleen of this case with decreased liver function and inflammation of spleen released high amount of Plasminogen Activator. Furthermore, we discussed the spleen might play some rule in the fibrinolytic system.