Pituitary-adrenal re onsireness after corticosteroid therapy in children with nepbrosis

S o M E a E G ~ M E N of intermittent corticosteroid therapy is usually recommended following remission of the nephrotic syndrome in children? 2, 3 Hatter, Reddy, and Thorn 4 reported some advantages in adults from the administration in a single dose every 48 hours of twice the daily maintenance dose of corticosteroids usually given for the control of asthma or rheumatoid arthritis. Soyka and Saxena ~ employed this mode of corticosteroid therapy in 6 children with nephrosis and noted satisfactory control of the nephrosis, whereas side effects were less severe than those expected from identical amounts of corticosteroids administered daily in divided doses. In two of their patients from whom measurements were obtained, the plasma cortisol level and the urinary