Use of Oral Oxytocics for Stimulation of Labor in Cases of Premature Rupture of the Membranes at Term: A randomized comparative study of prostaglandin E2 tablets and demoxytocin resoriblets

The efficacy of oral PGE2 tablets and buccal demoxytocin (resoriblets) for the induction of labor in cases of premature rupture of the membranes (PROM) after the 37th week of gestation has been evaluated in a prospective, randomized investigation of 193 women. PGE2 tablets (Pro-stinR) were given to 109 parturients and demoxytocin resoriblets (SandopartR) to 84. The former were given in increasing doses from an initial 0.5 mg to a maximum of 1.5 mg every hour. The demoxytocin was administered at a constant dosage of 50 I.U. every 30 min.The treatment was unsuccessful in 10 of the women treated with PGE2 tablets and in 19 women receiving demoxytocin resoriblets. In addition, the treatment had to be discontinued in 5 women in the PGE2 group due to gastrointestinal side effects. This gives a total success rate of 86.3% for treatment with PGE2 against 77.4% in respect of demoxytocin. This difference is not significant.No difference was observed between the two treatment groups as regards: the stimulation-deliv...