Measure equivalence rigidity of the handlebody groups

Let $V$ be a connected $3$-dimensional handlebody of finite genus at least $3$. We prove that the handlebody group $\mathrm{Mod}(V)$ is superrigid for measure equivalence, i.e. every countable group which is measure equivalent to $\mathrm{Mod}(V)$ is in fact virtually isomorphic to $\mathrm{Mod}(V)$. Applications include a rigidity theorem for lattice embeddings of $\mathrm{Mod}(V)$, an orbit equivalence rigidity theorem for free ergodic measure-preserving actions of $\mathrm{Mod}(V)$ on standard probability spaces, and a $W^*$-rigidity theorem among weakly compact group actions.