The new dimensions of warfarin prophylaxis

The Scope of Thromboembolism.- Vitamin K-Dependent Proteins.- The Biochemical Basis of Warfarin Therapy.- Warfarin and the Biochemistry of the Vitamin K Dependent Proteins.- Anticoagulation Proteins C and S.- Warfarin and Bone: Implications for Rational Strategies to Selectively Antagonize the Action of Vitamin K in Target Tissues.- Human Genes for Factor IX and Other Vitamin K Dependent Blood Proteins.- The Prothrombin Time.- Tissue Factor.- INR - Calibration of the Therapeutic Range.- Cold-Promoted Activation of Factor VII and Shortening of the Prothrombin Time.- Immunologic Aspects of Vessel Injury and Thrombosis.- What's The Dose?.- Venous Thromboembolism - Primary Prophylaxis.- Venous Thromboembolism in Moderate Risk Patients.- Two-Step Warfarin Therapy for the Prophylaxis of Venous Thrombosis after Elective Surgery.- Prevention of Venous Thromboembolism in High-Risk Patients by Prophylactic Administration of Oral Anticoagulants.- Genetic Coagulation Defects.- Venous Thromboembolism - Secondary Prophylaxis.- Treatment of First Episode of Venous Thrombosis.- Management of Recurrent Venous Thromboembolism.- Special Issues.- Warfarin Metabolism and Drug-Drug Interactions.- Improving the Benefit/Risk Ratio.- Oral Anticoagulant Therapy and Skin Necrosis: Speculations on Pathogenesis.- Cardiovascular - Arterial Thromboembolism.- Clinical Trials in Myocardial Infarction and Coronary Heart Disease.- Anticoagulants in Acute Myocardial Infarction.- Long-Term Anticoagulant Treatment after Acute Myocardial Infarction.- Following Coronary Thrombolysis.- Arterial Thromboembolism: Valvular Heart Disease and Prosthetic Heart Valves.- Neurovascular - Arterial Thromboembolism.- Clinical Trial Dilemmas and Cerebrovascular Disease.- Atrial Fibrillation and Stroke: The View from Cardiology.- Atrial Fibrillation and Stroke: The View from Neurology.- Cardiac Embolic Stroke: Anticoagulating the Elderly.- Anticoagulants for the Treatment of Transient Ischemic Attacks.- Epilogue.- Contributors.