Uterine papillary serous carcinoma

Uterine papillary serous carcinoma (UPSC) was first identified as a distinct histological entity in 1981 by Lauchlan and Hendrickson [17, 22]. It represents up to 10% of all endometrial cancers [5, 11, 13, 28, 35] but accounts for 50% of the recurrences in patients diagnosed with disease thought to be confined to the uterus [15, 17]. It is an aggressive histological type of endometrial cancer with early intraabdominal and lymphatic spread [11, 13, 28, 35], as observed in ovarian carcinomas. Therefore, a comprehensive surgical staging, optimal cytoreduction and adjuvant therapy are proposed to those women diagnosed with UPSC.