Prone to Supine Surface Based Registration Workflow for Breast Tumor Localization in Surgical Planning.

Breast cancer is the most frequent cancer in women worldwide. Screening programs and imaging improvements have increased the detection of clinically occult non-palpable lesions requiring preoperative localization. Image-guided wire localization (WGL) is the current standard of care for the excision of non-palpable carcinomas during breast conserving surgery (BCS). Due to the current limitations of intraoperative tumor localization approaches, the integration of the information from multimodal imaging may be especially relevant in surgical planning. This work presents a workflow to perform a prone image-to-surgical physical data alignment in order to determine the correspondence between the tumor identified in the preoperative image and the final position of the tumor in the surgical position. The evaluation of the methodology has been carried out in 18 cases achieving an average localization error of 10.40 mm and 9.84 mm in 11 small lesion cases (less than 1 cm in diameter).