Exogenous melatonin enhances the TRH-induced prolactin release in normally cycling women: A sex-specific effect

The aim of the present study was to analyze the effects of exogenous melatonin (MT) upon pituitary and adrenal responsiveness to releasing hormones in different phases of the menstrual cycle. We evaluated the response of FSH and LH to 100 pg gonadotropin releasing hormone, of TSH and prolactin (PRL) to 200 (ig thyrotropin releasing hormone (TRH), and of cortisol to 10 pg ACTH 1–17. We studied eight young women with normal ovulatory cycles in the early follicular (days 5–7) and luteal (days 22–24) phases. Stimulation tests were performed at 18.00 in baseline conditions as well as 1 h after oral intake of exogenous MT (2 mg as a gelatine capsule). We did not observe any significant change in FSH, LH, TSH and cortisol responses to their respective releasing hormones in either phase of the cycle. PKL response to TKH was higher after MT in the follicular phase, when evaluated in ternis of net increment and integrated area of response (p < 0.02 versus baseline conditions for both variables). In the luteal phase...