Efficacy and Safety of cilnidipine for mild and moderate primary hypertension
2005
Objective: To evaluate the efficacy and safety of cilnidipine domestically manufactured in the treatment of patients with mild to moderate primary hypertension. Methods: A randomized, double-blind, double-mimic controlled trial enrolled sixty-four patients with mild to moderate primary hypertension,who were randomized to administer either cilnidipine (5mg) or amlodipine (5mg) once daily for four weeks. After 4-week therapy, the patients who had not responded the therapy dose were doubled for additional 4 weeks. The blood pressure, heart rate, ECG, blood and urinary lab tests were comparable for the two treatment groups. Results: There was no significant difference in the reduction of both sitting systolic and diastolic pressure between the two treatment groups. Conclusion: Cilnidipine is safe and effective in the treatment of mild to moderate hypertension.
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