Hystiocytic sarcoma – a case report with the review of treatment
2011
A 45-year old woman presented with pain in her
right shoulder and neurologic symptoms in the
fingers of her right hand. An extradural tumor
mass was diagnosed at the level C6-Th2 and
was surgically removed. Pathology report was
consistent with histiocytic sarcoma. Additional
primary sites on PET-CT involved the right supraclavicular
lymph nodes and subcutaneous
tissue, liver, uterus and small bowel. After excision,
the tumor site was irradiated. When radiotherapy
was completed the patient was started
on cladribine, however, without success. She was
then started on thalidomide, however, the treatment
was discontinued because of peripheral
neuropathy. One cycle with CHOEP regimen
was administered but proved ineffective. She
failed an attempt to collect cells for autologous
hematopoietic stem-cell transplant. Unfortunately,
she was a poor mobilizer. Further on she
was treated with interferon, which was not successful
either. We proceeded with symptomatic
treatment.
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