Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren’s syndrome-like disease

Objective Sjogren’s syndrome is a chronic autoimmune disorder characterized by progressive lymphocytic infiltration within the salivary and lacrimal glands. The current study was undertaken to investigate the effects of innate immunity activation on sialoadenitis in a mouse strain genetically susceptible for development of Sjogren’s syndrome-like disease.