Three-DimensionalElectrodeposition of Calcium Phosphateson Porous Nanofibrous Scaffolds and Their Controlled Release of Calciumfor Bone Regeneration
2020
To mimic the bone
matrix of mineralized collagen and to impart
microporous structure to facilitate cell migration and bone regeneration,
we developed a nanofibrous (NF) polymer scaffold with highly interconnected
pores and three-dimensional calcium phosphate coating utilizing an
electrodeposition technique. The mineral content, morphology, crystal
structure, and chemical composition could be tailored by adjusting
the deposition temperature, voltage, and duration. A higher voltage
and a higher temperature led to a greater rate of mineralization.
Furthermore, nearly linear calcium releasing kinetics was achieved
from the mineralized 3D scaffolds. The releasing rate was controlled
by varying the initial electrodeposition conditions. A higher deposition
voltage and temperature led to slower calcium release, which was associated
with the highly crystalline and stoichiometric hydroxyapatite content.
This premineralized NF scaffold enhanced bone regeneration over the
control scaffold in a subcutaneous implantation model, which was associated
with released calcium ions in facilitating osteogenic cell proliferation.
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