P-0110 The Influence of Prognostic Factors on Survival in Patients with Advanced Pancreatic Cancer Evaluated in not Referred Centre

Abstract Introduction Pancreatic cancer (PC) is characterized by unfavorable outcome. More than 80% of patients (pts) are diagnosed in an advanced stage of disease, where the resection is no possible and the treatment goal is control of the symptoms and prolongation of survival. The aim of this study was to investigate the impact of clinical and serological factors on the survival in pts with locally advanced or metastatic PC. Methods Data of pts affected by PC were collected through chart review and included sex, age, symptoms at diagnosis time (abdominal pain, jaundice, nausea, vomiting, weight loss), smoking and alcohol habit, familiarity for neoplasia, site involved in the pancreas, metastasis, infiltration of duodenum wall, diabetes, levels of CEA, CA 19.9, AST, ALT, GGT, ALP, bilirubin, amylase, lipase. The influence of these clinical and serological factors on the survival was analyzed using Cox multivariate regression analysis. Median survival time was defined as the median interval between the PC diagnosis and death from any cause or last follow-up. Results We collected data of 70 PC pts (39 M, median age of 68 yrs) referred to our Gastrointestinal Unit from May 2006 to January 2012. At diagnosis abdominal pain was present in 46 pts, nausea in 17 pts, vomiting in 16 pts, weight loss in 24 pts, jaundice in 33 pts, diabetes in 20 pts. Median time between onset symptoms and diagnosis was 30 days (range 0-345 days). In 49 pts the site involved was the head and in 21 the body and tail. 36/67 pts were smokers. 27/67 pts were drinker. 4/66 pts had first degree relative affected by PC. During follow up 55/70 pts died. The median survival time was 116.5 days (range: 10-785 days) for all pts. Multivariate analysis showed that CA 19.9 (p=0.017), jaundice (p=0.033), AST (p=0.005) and ALT (p=0.009) were significantly associated with a worse survival. The remaining covariates were not predictors of survival. Conclusion In our preliminary results jaundice, serum level of CA 19.9, AST and ALT were associated with inferior survival in PC pts. Prognostic clinical and serological markers could be a helpful tool for improving outcome with the use of individualized treatment concepts.