Clinical observation of autologous bone marrow transfusion after chemotherapy in HIV infected patients with colorectal cancer

Objective To discuss the therapeutic effect of a treatment that collected and preserved autologous bone marrow before chemotherapy and transfused it into HIV infected patients upon how to reconstruct the marrow and immune system. Methods Thirteen HIV patients with colon cancer and 8 HIV infected patients with colorectal cancer were underwent surgery. After surgery, Twelve patients received regular chemotherapy. Nine patients′ marrow were collected when they were under surgery using infusion port that were planted through mesenteric venous. The marrow were persevered under -80℃. After chemotherapy, the marrow of each patients were transfused into her/his body through the planted infusion port. Then relative indicators were compared between the two groups. Results Before chemotherapy, the peripheral blood pictures difference of the two groups of patients′ lymphocyte subpopulation is not significance. After surgery, the group of marrow preservation and transfusion have significant higher CD4+ T counts than the control group at the 24 month (t=4.58, P<0.001). The average CD8+ T counts of marrow preservation and transfusion group were higher than the control group, but no significance. The WBC counts were higher than control group. The significant difference occurred at first, third and the sixth chemotherapy (t=4.08, P<0.001, t=7.18, P<0.001, t=7.74, P<0.01). The average blood platelets level was higher than the control group, but no significance. The average hemoglobin level was higher. The significant difference occurred at first and sixth chemotherapy (t=2.43, P=0.03, t=2.51, P=0.02). Two patients in marrow preservation and transfusion group died from metastasis in two years (2/9). Four patients in control group died died from metastasis in two years (4/12). The difference was not significant (P=0.66). Conclusion It can improve the growth of WBC to collecting marrow before chemotherapy and transfusion after chemotherapy. The therapeutic effect of reconstructing the marrow and immune system requires further research. Key words: Colorectal neoplasms; Chemotherapy; HIV infection; Bone marrow autologous transfusion; Immune reconstruction