Serum levels of inhibin B are altered in premature ovarian failure

Objective:To explore the relationship between serum inhibin B and premature ovarian failure(POF).Methods:Serum levels of inbibin B on cycle day 3 were determined by a solid quantitative sandwich enzyme immunoassay technique(Sandwich ELISA) both in POF group and in control(womem without POF),and relationship between inhibin B and FSH,relationship between inhibin B and E_2 were analyzed.Results:Mean(±SD)concentrations of inhibin B were lower(P0.0001)in POF (36.8±17.0) pg/ml than controls(109.0±35.0) pg/ml.In all women,nonparametric correlations analysis demonstrated that inhibin B serum levels were negatively correlated with FSH(r=-0.644,P0.001) and positively correlated with E_2(r=0.427,P0.01).Conclusion:Lower concentrations of inhibin B may be partly responsible to POF through a special way.