Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

Sascha Rutz,Nobuhiko Kayagaki,Qui T. Phung,Celine Eidenschenk,Rajkumar Noubade,Xiaoting Wang,Justin Lesch,Rongze Lu,Kim Newton,Oscar W. Huang,Andrea G. Cochran,Mark Vasser,Benjamin P. Fauber,Jason DeVoss,Joshua D. Webster,Lauri Diehl,Zora Modrusan,Donald S. Kirkpatrick,Jennie R. Lill,Wenjun Ouyang,Vishva M. Dixit

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

2015

The deubiquitinase enzyme DUBA is shown to act as a negative regulator of interleukin-17A (IL-17A) in TH17 cells; DUBA interacts with and stabilizes the ubiquitin ligase UBR5, which in turn targets RORγt for degradation in the proteaseome, thus limiting IL-17A production.

Keywords:

Ubiquitin ligase
Deubiquitinating enzyme
Interleukin 17
Enzyme
Cancer research
RAR-related orphan receptor gamma
Acquired immune system
Limiting
Immunology
Biology
Ubiquitin
Transforming growth factor beta
Proteasome
Cell biology
Transcription factor

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