A short synthesis of 5′-O-trityl-protected threo- and erythro- 3′-cyano-3′-deoxythymidine epimers using free-radical chemistry

A reinvestigation of a synthetic route to 5′-O-trityl-protected erythro-CNT that incorporates a modification of the Stork radical cyclization-cyanation reaction generates an unexpected threo-epimer.