liposomal composition containing an active ingredient for the relaxation of smooth muscle, making such a composition and therapeutic use.

pharmaceutical composition for topical administration with an active ingredient included in liposomes directly or indirectly exerts a relaxing effect on the smooth muscle, wherein the liposomes have a molar ratio of cholesterol from 0 to 50%, preferably 30 to 45%, relative to the total amount of lipids, and present within an aqueous environment with a pH in the range of 2.5 to 5.5 containing at least one protonated group consisting of prostaglandins, adenylate cyclases, cAMP active ingredient, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), compounds of NO, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases in a concentration of at least 100 nmol per umol lipid, and wherein in outside the liposomes exists an aqueous environment with a neutral or alkaline pH.