Lymphoproliferative disorders of the ocular adnexa.

PURPOSE OF REVIEW: To describe recent advances in clinical features, diagnostic tools, and treatment modalities for lymphoproliferative diseases affecting the ocular adnexa. RECENT FINDINGS: A close relationship of non-Hodgkin lymphoma with long-term use of aspirin and nonaspirin nonsteroidal antiinflammatory drugs has recently been documented. Some infectious agents have also been implicated in the pathogenesis of lymphomas. The advent of immunohistochemistry and polymerase chain reaction have helped to distinguish between benign lymphoproliferation and malignant lymphoma. New techniques for radiation therapy are proposed to decrease complication rates associated to this treatment. SUMMARY: Recent studies demonstrated that ocular adnexal lymphomas may be masked by a number of different diseases and clinical features. Prognosis depends on the stage and histology of lymphoma as well as the location.