Antibody‐Catalyzed Rearrangement of the Peptide Bond.
1993
The generation of antibodies from a bifunctional cyclic phosphinate transition-state analog provided agents capable of efficiently catalyzing both steps of the overall conversion of a substrate containing an asparaginyl-glycyl sequence through a succinimide intermediate to the products aspartyl-glycyl and the rearranged isoaspartyl-glycyl sequence. This reaction provides a potential means in addition to amide cleavage for the deactivation of protein or peptide biological functions in vivo.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
1
References
1
Citations
NaN
KQI