Three-Component Condensation of 1,2,4-Triazol-3-amine with Cyclohexanone and ortho-Substituted Benzaldehydes

Three-component condensation of 1,2,4-triazol-3-amine with cyclohexanone and ortho-substituted benzaldehydes afforded mixtures of angularly and linearly fused aryl-substituted hexahydrotriazoloquinazolines and octahydrotriazoloquinazolines whose structure was determined by using one- and two-dimensional NMR spectroscopy. A probable scheme of product formation was proposed.