Tethered Ruthenium( II ) Catalysts in Asymmetric Transfer Hydrogenation

This chapter describes the discovery and development of Ru(II)-tethered catalysts for the asymmetric transfer hydrogenation of ketones and imines. Aspects of catalyst design and activity are described, as are the applications of the catalysts, notably to industrially relevant targets. This class of catalyst has enjoyed a significant amount of interest from researchers worldwide and offers exciting prospects as a practical reagent in both industrial and academic laboratories.