Tu1483 Anti-PBP Antibodies Not Usefull to Identify Autoimmune Pancreatitis in Dutch Cohort
2015
to respond to initial steroids, and 12 experienced a relapse (average time to relapse was 577 +/-799 days). Among patients who failed the steroid taper or who relapsed, 10 were treated with a second course of prednisone, 6 with azathioprine, 1 with rituximab, 1 with mycophenolate, and 3 remained on low-dose steroids indefinitely. Among AIP2 patients, one failed to taper steroids and remains on low-dose indefinitely, but no relapses have been observed. Rates of endoscopic balloon dilation of strictures and stenting varied between AIP1 and 2 patients (21 vs 25%, and 96 vs 75%, respectively), but were not statistically significant. Conclusions: 1) AIP1 and 2 patients varied demographically and by baseline lab values. 2) Improved early diagnostic testing may reduce the number of surgeries. 3) Over a third of AIP1 patients did not respond or relapsed after initial prednisone treatment. 4) Despite a smaller AIP2 cohort size and shorter clinical follow up, our data suggest AIP1 patients may require more aggressive initial and recurrent medical management.
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