Influence of MNRI on the Immune Status of Children with Down Syndrome
2017
The clinical and immunological characteristics of 49 children with Down syndrome were studied. Thirty-four boys
and 15 girls between the ages of zero and six years old were observed.
It was revealed that children in the Study Group with Down syndrome developed a greater number of disorders
starting at the earliest stages of pregnancy and delivery, such as fetal malnutrition, congenital heart defects, and
pathology of vision, than children in the control group (p<0.05). All of the children in the Study Group had allergic
reactions and were frequently ill. There was a noticed decrease in the numbers of subpopulations of T-lymphocytes
(СD45/CD3), CD3/CD4, CD3/CD8 and the absolute number of B-cells (CD45/CD19), and at IgG pool, indicating a
certain deficiency in cell-mediated and humoral immune responses which provides a base for frequent diseases,
including bacterial diseases. Also an increase in the prevalence of pre-activated cells (CD45/CD25) and NK
cells (CD16/CD32/CD56), and a clear increase of IgE (1489.5 ± 467.9 и 59.67 ±11.8 IU/L in the control group,
p<0.05) was noted, which explains the predisposition in children with Down syndrome to IgE-dependent humoral
immune responses and allergic reactions. These specific indictors served as evidence that an evaluation of MNRI
as a therapeutic program for improved immunity could be very beneficial. Tests done after two weeks of MNRI
therapy showed normalizing of a significant number of abnormal indicators of T- and B- lymphocytes, NK-cells,
immunoglobulin levels, and pro- and anti-inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, IL-12, IL-17, IFN-γ, TNF-α).
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