Association of increased time from chemoradiation (CRT) to esophagectomy (E) with increased surgical complications (Cx) in esophageal cancer (EC).

77 Background: EC is often treated with CRT followed by E. E is typically performed 6 weeks after completion of CRT, but the optimal timing is unknown. Previous work has shown that a longer time interval (TI) between CRT and E resulted in a higher percentage of patients (pts) with pathologic complete response. This study was undertaken to determine whether this improved response comes at the expense of increased surgical Cx. Methods: Complete records were available for 85 pts who underwent CRT and subsequent E at a single academic center from 2001-2011. Surgical Cx were collected. Univariable and multivariable analyses were performed to investigate the association between length of TI from CRT to E and Cx, adjusting for age, gender, and surgery type. Multiple linear regression was performed to examine the association of length of stay (LOS) and estimated blood loss (EBL) with TI, adjusting for covariates. Results: Of 85 patients, 72 were male and the histology was adenocarcinoma in 72. The median age was ...