Solvent-Free Synthesis of 1,5-Disubstituted Tetrazoles Derived from Baylis-Hillman Acetates as Potential TNF-α Inhibitors.

Solvent free multicomponent reaction of Baylis Hillman acetate, TMS azide and arylnitrile to produce 1,5-disubstituted tetrazole is described. Some of these tetrazoles are found to be potential TNF-α inhibitors.