TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis

M-F Pang,A-M Georgoudaki,L. Lambut,Joel Johansson,Vedrana Tabor,Kazuhiro Hagikura,Yi Jin,Malin Jansson,J. S. Alexander,Celeste M. Nelson,Lars Jakobsson,Christer Betsholtz,Malin Sund,Mikael C. I. Karlsson,Jonas Fuxe

TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis

2016

M-F Pang
A-M Georgoudaki
L. Lambut
Joel Johansson
Vedrana Tabor
Kazuhiro Hagikura
Yi Jin
Malin Jansson
J. S. Alexander
Celeste M. Nelson
Lars Jakobsson
Christer Betsholtz
Malin Sund
Mikael C. I. Karlsson
Jonas Fuxe

Tumor cells frequently disseminate through the lymphatic system during metastatic spread of breast cancer and many other types of cancer. Yet it is not clear how tumor cells make their way into the ...

Keywords:

C-C chemokine receptor type 7
Cancer research
Chemotaxis
Breast cancer
Immunology
Epithelial–mesenchymal transition
CCL21
Cancer
Lymph node stromal cell
Lymphatic system
Biology
Mammary tumor
Inflammation
Paracrine signalling

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