Mast Cells and Serotonin Synthesis Modulate Chagas Disease in the Colon: Clinical and Experimental Evidence

Vinicius Kannen,Juliana Yumi Sakita,Zumira A. Carneiro,Michael Bader,Natalia Alenina,Regina R. Teixeira,Enio Chaves de Oliveira,Mariângela Ottoboni Brunaldi,Bianca Gasparotto,Daniela C. Sartori,Cleverson Rodrigues Fernandes,João S. Silva,Marcus V. Andrade,Wilson A. Silva,Sérgio A. Uyemura,Sérgio Britto Garcia

Mast Cells and Serotonin Synthesis Modulate Chagas Disease in the Colon: Clinical and Experimental Evidence

2018

Vinicius Kannen
Juliana Yumi Sakita
Zumira A. Carneiro
Michael Bader
Natalia Alenina
Regina R. Teixeira
Enio Chaves de Oliveira
Mariângela Ottoboni Brunaldi
Bianca Gasparotto
Daniela C. Sartori
Cleverson Rodrigues Fernandes
João S. Silva
Marcus V. Andrade
Wilson A. Silva
Sérgio A. Uyemura
Sérgio Britto Garcia

Background Trypanosoma cruzi (T. cruzi) infects millions of Latin Americans each year and can induce chagasic megacolon. Little is known about how serotonin (5-HT) modulates this condition. Aim We investigated whether 5-HT synthesis alters T. cruzi infection in the colon.

Keywords:

Internal medicine
Megacolon
Chagas disease
Serotonin synthesis
Diabetes mellitus
Immunology
Endocrinology
Medicine
Trypanosoma cruzi
Serotonin
Case-control study
Tryptophan hydroxylase
Hepatology

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