Diversité et sensibilité aux antibiotiques de différentes espèces de Pseudomonas à l’Hôpital de l’Amitié Sino-Guinéenne, Kipé/Conakry

Introduction: Infections caused by different species of Pseudomonas are amongst leading causes of morbidityand mortality worldwide. The aim of this study was to determine different species of Pseudomonas isolated frombiological fluids between Jun 2014 and Jun 2018 at China-Guinea friendship hospital of Kipe/Conakry, and todescribe their antibiotic sensitivity patterns. Material and methods: Bacterial identification and antibiograms aswell as determination of minimal inhibitory concentrations (MICs) were performed on Vitek2 Compact 15.Results: Seventy-five isolates of Pseudomonas belonging to six different species were identified: Pseudomonasaeruginosa (44), Pseudomonas luteola (15), Pseudomonas fluorescens (13), Pseudomonas mendocina (1),Pseudomonas oryzihabitans (1) and Pseudomonas putida (1). The patients mean age was 49,12±23,48 years [18days-90 years] and the sexe-ratio (M/F) = 0,875. The majority of the isolates was susceptible to imipenem(93,33%), amikacin (88,00%), gentamicin (72,00%), tobramycin (70,66%), piperacillin/tazobactam (70,66%),ceftazidime (60,00%), cefotaxime (54,66%), ofloxacin (57,33%) and ciprofloxacin (58,66%). On the otherhands, these isolates were resistant to ampicillin (89,33%), trimethoprim/sulfamethoxazol (89,33%), nalidixicacid (85,33%), cefalotin (77,33%), ticarcillin (68,00%), cefoxitin (64,00%), and nitrofurantoine (57,33%).Multidrug-resistance patterns with high MIC levels were observed particularly for the isolate N°64 from aurinary tract infection of 82 years old patient. This isolate was resistant to all antibiotics tested. Conclusion: Ourstudy revealed 75 isolates of Pseudomonas belonging to six species, carrying a multidrug-resistance phenotypeto all antibiotic families tested in Guinea