Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/β-Catenin Complexes in Adherens Junctions

Doo Jae Lee,Dong-Hoon Kang,Mina Choi,Yang Ji Choi,Joo-Young Lee,Joo Hyun Park,Yoon Jung Park,Kyung Wha Lee,Sang Won Kang

Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/β-Catenin Complexes in Adherens Junctions

2013

Doo Jae Lee
Dong-Hoon Kang
Mina Choi
Yang Ji Choi
Joo-Young Lee
Joo Hyun Park
Yoon Jung Park
Kyung Wha Lee
Sang Won Kang

In discovering a specific antioxidant enzyme that can repress melanoma metastasis, this study also suggests a tractable new direction to treat this deadly disease.

Keywords:

Melanoma
Enzyme
Peroxiredoxin 2
Adherens junction
Cadherin
Catenin
Immunology
Metastasis
Biology
Gene silencing
Ectopic expression

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