Low hygroscopic aripiprazole drug compound and the process feed for the preparation thereof

Michiaki Tominaga,Takuji Bando,Satoshi Aoki,Junichi Kawasaki,Makoto Ishigami,Youichi Taniguchi,Tsuyoshi Yabuuchi,Kiyoshi Fujimoto,Yoshihiro Nishioka,Noriyuki Kobayashi,Tsutomo Fujimura,Masanori Takahashi,Kaoru Abe,Tomonori Nakagawa,Koichi Shinhama,Naoto Utsumi,Yoshihiro Oi,Shohei Yamada,Kenji Tomikawa

Low hygroscopic aripiprazole drug compound and the process feed for the preparation thereof

2003

Michiaki Tominaga
Takuji Bando
Satoshi Aoki
Junichi Kawasaki
Makoto Ishigami
Youichi Taniguchi
Tsuyoshi Yabuuchi
Kiyoshi Fujimoto
Yoshihiro Nishioka
Noriyuki Kobayashi
Tsutomo Fujimura
Masanori Takahashi
Kaoru Abe
Tomonori Nakagawa
Koichi Shinhama
Naoto Utsumi
Yoshihiro Oi
Shohei Yamada
Kenji Tomikawa

The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.

Keywords:

Combinatorial chemistry
Solubility
Drug compound
Aripiprazole
Chemistry
Hydrate

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