Inherited diseases and syndromes leading to aortic aneurysms and dissections

Summary Genesaffect virtually all human characteristics and diseases. These influencescan be ascertained in individual patients through a reviewof the family history, physicalexamination and the useof medicaldiagnostics.Aneurysms anddissectionsarea leadingcauseof morbidityand mortality, in addition to medical expense, and, on the whole, their specific molecular mechanisms are beginning to be identified. Over the past decade, genetic tests have become available for numerous heritable disorders especially inherited with mendelian models. An important fact is that the results of genetic tests may also be useful beyond the individual affected by the genetic disorder. Depending upon the disorder, knowledge of carrier status may be important. Because of these facts, some essential information regarding basic genetics of aneurysm and dissection has been presented in this study. # 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.