Tacrolimus Dose Optimization Strategy for Refractory Ulcerative Colitis Based on the Cytochrome P450 3A5 Polymorphism Prediction Using Trough Concentration after 24 Hours.

Motoyuki Onodera,Katsuya Endo,Takeo Naito,Rintaro Moroi,Masatake Kuroha,Yoshitake Kanazawa,Tomoya Kimura,Hisashi Shiga,Yoichi Kakuta,Kenichi Negoro,Yoshitaka Kinouchi,Tooru Shimosegawa

Tacrolimus Dose Optimization Strategy for Refractory Ulcerative Colitis Based on the Cytochrome P450 3A5 Polymorphism Prediction Using Trough Concentration after 24 Hours.

2018

Motoyuki Onodera
Katsuya Endo
Takeo Naito
Rintaro Moroi
Masatake Kuroha
Yoshitake Kanazawa
Tomoya Kimura
Hisashi Shiga
Yoichi Kakuta
Kenichi Negoro
Yoshitaka Kinouchi
Tooru Shimosegawa

Background: In the tacrolimus treatment for refractory ulcerative colitis (UC), dose adjustment is necessary because the required doses to keep appropriate drug c

Keywords:

Endocrinology
Refractory
Drug
Gastroenterology
Trough Concentration
Diabetes mellitus
Polymorphism (computer science)
Tacrolimus
CYP3A5
Internal medicine
Ulcerative colitis
Medicine
Remission Induction Therapy
Pharmacokinetics

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