Associated non-ovarian problems of polycystic ovarian disease: insulin resistance

: It is evident from our current knowledge that women with PCO exhibit hyperinsulinaemia and are insulin resistant. Nevertheless, it remains to be determined whether the relationship of androgen to insulin is one of cause or effect in this syndrome. Elucidation of this mechanism may permit identification of the role of hyperinsulinism in the genesis or pathophysiology of this disorder.