IDX-899, an aryl phosphinate-indole non-nucleoside reverse transcriptase inhibitor for the potential treatment of HIV infection

infections and mortality in patients infected with HIV-1 [969323]. Classes of antiretroviral agents used for the treatment of HIV infection include nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), fusion inhibitors, integrase inhibitors and CCR5 antagonists [969323]. First-generation NNRTIs, such as efavirenz and nevirapine, are commonly prescribed as part of initial therapy for treatment-naive patients. However, a low genetic barrier for the development of