Clinical Observation of Efficacy of Docetaxel in the Treatment of Advanced Breast Cancer

OBJECTIVE:To observe the clinical efficacy,safety,the maximal tolerated dose(MTD) and dose-limiting toxicity(DLT) of docetaxel(TXT) in the treatment advanced breast cancer.METHODS:Docetaxel was given by drip infusion in escalating doses from the initial dose of 65 mg·m-2 to 75 mg·m-2 and 85 mg·m-2 until the appearance of DLT.RESULTS:Among the 15 cases,1 case with CR,5 PR,4 SD,and 5 PD.The DLT of TXT was neutropenia,and its MTD was 85 mg·m-2.CONCLUSION:Docetaxel(at a dose of 75 mg·m-2) showed remarkable efficacy and good tolerance in patietns with advanced breast cancer.