The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice.

Tamzin L. Ripley,Sandra Sanchez-Roige,Edward T. Bullmore,Manolo Mugnaini,Kay Maltby,Sam R. Miller,David R Wille,Pradeep J. Nathan,David N. Stephens

The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice.

2015

Tamzin L. Ripley
Sandra Sanchez-Roige
Edward T. Bullmore
Manolo Mugnaini
Kay Maltby
Sam R. Miller
David R Wille
Pradeep J. Nathan
David N. Stephens

Rationale Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed treatment of alcohol dependence, on ethanol consumption in mice.

Keywords:

Endocrinology
Antagonist
Internal medicine
Receptor antagonist
μ-opioid receptor
Anesthesia
Self-administration
Ethanol
Psychology
Naltrexone
Inverse agonist
Alcohol dependence
Pharmacology

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