Synthesis of Blonanserin

4-Fluorobenzoylcatonitrile,which was synthesized from methyl 4-fluorobenzoate and acetonitrile,reacted in the presence of polyphosphoric acid to give 3-(4-fluorophenyl)-3-oxopropanamide,followed by the cyclization with cyclooctanone,chlorination with phenylphosphonic dichloride and condensation with N-ethylpiperazine,to give blonanserin with an overall yield of about 42%.